49ers Schedule 2025 Home Games Schedule. The team is scheduled to play in six prime time games during the regular season in 2025, including four at home, with two on monday night (week 1 vs. Below are the dates and times (if known) for 49ers games during the upcoming season and who reported each matchup.
Check out the 49ers home and away matchups for the 2025 regular season. November 14, 2025 6:15 am pt.